서울대학교 공과대학 화학 생물 공학부 단백질신소재 연구실
  ·RESEARCH

[뿰援]

蹂 뿰援ъ떎뿉꽌뒗 뙆궓뒯뵪蹂묒쓽 遺꾩옄썝씤쑝濡 븣젮졇 엳뒗 옄湲곗“由쎌꽦 떒諛깆쭏 븣뙆-떆돱겕由(a-Synuclein, aS)쓣 솢슜븯뿬 겕寃 몢 媛吏 遺꾩빞 - [I] 븘諛濡쒖씠뱶 愿젴 떒諛깆쭏 옄湲곗“由쏀솕 썝由 諛 꽭룷룆꽦 젣뼱 뿰援 [II] 븣뙆-떆돱겕由/湲덈굹끂엯옄 蹂듯빀泥닿린諛 븯씠釉뚮━뱶 냼옱 媛쒕컻 諛 쓳슜 - 벑쓽 뿰援щ 닔뻾븯怨 엳쓬.

[I] 븘諛濡쒖씠뱶 愿젴 떒諛깆쭏 옄湲곗“由쏀솕 썝由 諛 꽭룷룆꽦 젣뼱 뿰援





(1) 븘諛濡쒖씠뱶 삎꽦 떒諛깆쭏 옄湲곗“由쏀솕 湲옉 뿰援


臾쇰━ 諛 솕븰쟻 쇅遺옄洹뱀뿉 뵲瑜 aS 삱由ш퀬癒몄쓽 떒쐞議곕┰솕 湲곗옉 뿰援
aS 솢꽦삎 삱由ш퀬癒 듅꽦 遺꾩꽍
솢꽦삎 삱由ш퀬癒 諛 떒쐞議곕┰솕 젣뼱瑜 넻븳 뙆궓뒯뵪蹂묒쓽 吏꾨떒 諛 移섎즺梨 媛쒕컻

(2) aS 삱由ш퀬癒몄쓽 吏吏덈쭑 뙆愿댁뿉 뵲瑜 꽭룷룆꽦 쑀룄 諛 젣뼱梨 媛쒕컻 뿰援

 
蹂 뿰援ъ뿉꽌뒗 뇤꽭룷궗硫몄쓽 썝씤쓣 鍮꾩젙긽쟻 떒諛깆쭏쓳吏묓쁽긽뿉 쓽븳 븘諛濡쒖씠뱶쓽 뿭븰쟻 슚怨 痢〓㈃뿉꽌 젒洹쇳븿쑝濡쒖뜥 눜뻾꽦 떊寃쎌쭏솚씤 뙆궓뒯뵪蹂묒쓽 遺꾩옄蹂묒씤쓣 씠빐븯怨 떊빟寃잛쓣 깉濡寃 젙쓽븯怨좎옄 븿. 듅엳, 꽭룷궡 吏吏덈쭑 援ъ“臾쇱쓽 鍮꾩젙긽쟻 뙆愿댄쁽긽뿉 誘몄튂뒗 븘諛濡쒖씠뱶 삎꽦쓽 뿭븰쟻 슚怨쇰 뿰援ы븿쑝濡쒖뜥 꽭룷눜솕쓽 썝씤쓣 洹쒕챸븯怨 洹 빐寃곗콉쓣 젣떆븯怨좎옄 븿.

aS 삱由ш퀬癒몄쓽 떒쐞議곕┰솕 씠뿉 뵲瑜 吏吏덈쭑 援ъ“蹂삎 諛 뙆愿 愿젴 뿰援щえ뜽:
吏吏덈쭑 몴硫댁뿉꽌 諛쒖깮븯뒗 븣뙆-떆돱겕由 삱由ш퀬癒몄쓽 떒쐞議곕┰솕 쁽긽
諛⑹궗삎 븘諛濡쒖씠뱶 꽟쑀泥 꽦옣怨 吏吏덈쭑 뙆愿댄쁽긽



뿰援щ궡슜
吏吏덈쭑뿉 븳 솢꽦삎 븣뙆-떆돱겕由 삱由ш퀬癒몄쓽 듅꽦遺꾩꽍 諛 吏吏덈쭑 뙆愿닿린옉 뿰援
삱由ш퀬癒 쑀룄 諛 遺꾪빐 씤옄 뿰援
삱由ш퀬癒 긽샇옉슜꽦 遺꾩옄 솕빀臾 뒪겕由щ떇 諛 듅꽦 遺꾩꽍쓣 넻븳 뙆궓뒯뵪蹂묒쓽 吏꾨떒 諛 移섎즺梨 媛쒕컻

(3) 떒諛깆쭏 珥덈텇옄援ъ“泥 젣옉 諛 쓳슜

aS 紐⑤끂癒몄 삱由ш퀬癒몄쓽 옄湲곗“由쏀솕 怨쇱젙뿉 떎뼇븳 쇅遺옄洹(뿴泥섎━, 湲됱냽깋媛, 쟾떒쓳젰 벑)쓣 媛븿쑝濡쒖뜥 떒諛깆쭏 븘由, 以묎났삎 굹끂援ы삎泥, 怨깆뒳삎 븘諛濡쒖씠뱶뿉 쓽븳 븯씠뱶濡쒖젮 벑쓣 젣옉븯怨, 씠瑜 愿묎꼍옉 떆뒪뀥, 臾쇱쭏 닔넚/슫諛섏껜, 깮臾쇳븰쟻 異⑹쭊냼옱, 슚냼 諛 꽭룷 怨좎젙솕 硫뷀듃由뒪 벑쑝濡쒖쓽 쓳슜꽦쓣 吏꾪븿.

aS 삱由ш퀬癒몄쓽 湲됱냽깋媛 議곕┰솕瑜 넻븳 以묎났삎 굹끂援ы삎泥 젣옉



뿰援щ궡슜
뼹쓬몴硫댁긽 aS 삱由ш퀬癒 옄湲곗“由쏀솕 湲곗옉 뿰援
Coffee Stain 슚怨쇱뿉 뵲瑜 以묎났삎 굹끂援ы삎泥 삎꽦湲곗옉 뿰援
쇅遺옄洹뱀뿉 쓽븳 諛⑹궗삎 굹끂꽟쑀泥 쑀룄湲곗옉 諛 쓳슜

[II] 븣뙆-떆돱겕由/湲덈굹끂엯옄 蹂듯빀泥닿린諛 븯씠釉뚮━뱶 냼옱 媛쒕컻 諛 쓳슜



쇅遺옄洹뱀뿉 諛섏쓳븯뒗 옄湲곗“由쎌꽦 떒諛깆쭏씤 aS瑜 씠슜븯뿬 湲덈굹끂엯옄(AuNP)쓽 蹂듯빀泥대 젣옉븯怨, 떒諛깆쭏 aS쓽 옄湲곗“由쏀솕 듅꽦怨 留뚮뒫 몴硫댄씉李 뒫젰쓣 솢슜븯뿬 湲덈굹끂엯옄쓽 1D, 2D, 3D 떎李⑥썝 援ъ“臾쇱쓣 젣옉븯怨, 떎怨듭꽦 떎由ъ뭅 굹끂엯옄 벑怨쇱쓽 쑖蹂듯빀泥대 젣옉븿쑝濡쒖뜥 냼봽듃濡쒕낫떛뒪, 諛붿씠삤꽱꽌, 愿묒쟾옄냼옄, 굹끂뵒諛붿씠뒪, 吏덊솚긽 뀒씪끂뒪떛뒪, 꽭룷깮옣 룄떆뒪뀥, 꽭룷-湲곌퀎 씤꽣럹씠뒪 遺꾩빞濡쒖쓽 쓳슜꽦쓣 吏꾪빐 굹媛怨좎옄 븿.

(1) aS-湲곕컲 떒諛깆쭏-굹끂 븯씠釉뚮━뱶 援ъ“泥 젣옉 諛 쓳슜



뿰援щ궡슜
뵾蹂듬떒諛깆쭏 aS怨쇱쓽 긽샇옉슜꽦 솕빀臾(쟾룄꽦 怨좊텇옄, 愿묐컲쓳꽦 솕빀臾) 몴硫 怨좎젙솕瑜 넻븳 떎湲곕뒫꽦 쑖빀냼옱 媛쒕컻
湲덈굹끂엯옄쇅 떎뼇븳 굹끂엯옄瑜 솢슜븳 떎李⑥썝 援ъ“泥 媛쒕컻 諛 쓳슜 (뵆옓꽌釉 諛쒓킅냼옄, 쑀룞삎 諛뺣쭑, 떎湲곕뒫꽦 留됱꽱꽌)
빟臾쇱쟾떖슜 湲곕뒫꽦 긽泥섏쿂移섏젣, 愿묐컲쓳꽦 씤怨듭떆媛 냼옄, 諛붿씠삤-씤꽣럹씠뒪슜 꽭룷移 媛쒕컻
몿
愿묒뿴/愿묒뿭븰(Photothermal/Photodynamic) 슚怨쇰 솢슜븳 븫꽭룷 눜移 쟾왂梨 젣떆

(2) aS-굹끂 븯씠釉뚮━뱶 援ъ“泥 븿쑀 愿묎뎄룞삎 냼옱 媛쒕컻



쇅遺쓽 臾쇰━솕븰쟻 옄洹뱀쓣 媛먯븯怨 씠瑜 냼옱쓽 겕湲곕굹 삎깭쓽 媛뿭쟻 蹂솕濡 쟾솚븯뒗 臾댁쟾썝 媛룞냼옱 媛쒕컻 臾쇱껜쓽 吏곸엫쓣 슂援ы븯뒗 떎뼇븳 옣鍮꾩쓽 二쇱슂 援ъ꽦슂냼濡 솢슜맆 닔 엳쑝硫, 媛꾨떒븳 湲곌퀎 젣옉쑝濡쒕꽣 泥⑤떒 슦二쇨났븰 諛 쓽怨듯븰 遺꾩빞뿉 씠瑜닿린源뚯 愿묐쾾쐞븳 遺꾩빞濡쒖쓽 쟻슜 媛뒫븳 빑떖냼옱씪뒗 痢〓㈃뿉꽌 쓽誘멸 엳쓬. 蹂 뿰援ъ뿉꽌뒗 愿묎컧쓳꽦 굹끂냼옱씤 湲덈굹끂엯옄 깂냼굹끂뒠釉뚮 aS瑜 씠슜븯뿬 떎李⑥썝 굹끂援ъ“臾쇰줈 젣옉븯怨, 씠瑜 怨좉컯룄 삩룄媛먯쓳꽦 븯씠뱶濡쒖젮뿉 궗쟾 꽕怨꾩뿉 뵲씪 꽑깮쟻쑝濡 룄엯븿쑝濡쒖뜥 떎뼇븳 吏곸엫씠 媛뒫븳 愿묎뎄룞삎 삎긽蹂솚 냼옱瑜 젣옉븿쑝濡쒖뜥 沅곴레쟻 留덉씠겕濡쒕㉧떊 젣옉쓣 쐞븳 援먮몢蹂대 솗蹂댄븯怨좎옄 븿.

뿰援щ궡슜
愿묎컧쓳꽦 AuNP/CNT-븿쑀 怨좎냽諛섏쓳꽦, 怨좎떊異뺤꽦, 怨좉컯룄 븯씠뱶濡쒖젮 젣옉
솢꽦 븯씠뱶濡쒖젮쓣 솢슜븳 湲곕낯 諛 쓳슜 룞옉援ы쁽 떒쐞援щ룞泥 젣옉
깮泥닿린愿 紐⑥궗떆뒪뀥 媛쒕컻
몿
愿묎뎄룞/諛뺣룞삎 빟臾쇰갑異 諛 씤怨듬궡遺꾨퉬 떆뒪뀥 媛쒕컻
빐뼇깮臾(빐뙆由, 留먮몄옒, 議곌컻) 紐⑥궗떆뒪뀥 媛쒕컻





(3) aS-AuNP 떎怨듭꽦 떎由ъ뭅 굹끂엯옄 蹂듯빀泥 젣옉쓣 넻븳 떎以묎린뒫꽦 뀒씪끂뒪떛(Theranostic) 굹끂援ъ“泥 젣옉 뿰援
 


뿰援щ궡슜
aS 由ш컙뱶瑜 솢슜븳 꽑깮쟻 빟臾 諛⑹텧젣뼱슜 떎怨듭꽦 떎由ъ뭅 굹끂엯옄湲곕컲 엯옄긽-엯옄 援ъ“泥(PoP; Particles-on-a-Particle) 젣옉怨 怨좏슚쑉 빟臾쇱쟾떖 떆뒪뀥 媛쒕컻
DNA siRNA 벑 쑀쟾옄쓽 꽭룷궡 룄엯쓣 넻븳 쑀쟾옄 knock-down 諛 떒諛깆쭏 怨쇰컻쁽 쑀룄梨 젣떆 씠瑜 솢슜븳 쑀쟾옄 諛쒗쁽젣뼱/꽭룷移섎즺 벑 遺꾩옄깮臾쇳븰 諛 쓽빟븰 遺꾩빞 쓳슜
떎뼇븳 굹끂엯옄(, , 옄꽦 굹끂엯옄 諛 뼇옄젏) 諛 깮由ы솢꽦 臾쇱쭏쓽 떒씪 떎由ъ뭅 굹끂엯옄 몴硫댁긽 吏묒쟻솕瑜 넻븳 떎以묎린뒫꽦 뀒씪끂뒪떛 굹끂援ъ“泥 媛쒕컻



 

ADVANCED PROTEIN MATERIALS LABORATORY, SCHOOL OF CHEMICAL & BIOLOGICAL ENGINEERING
SEOUL NATIONAL UNIVERSITY, 302-218, SAN 56-1, SHILIM-DONG, GWANAK-GU, SEOUL, 151-744, KOREA
TEL: Professor 02) 880-7402, Lab. 02) 880-7414, ICP 02) 876-7414, FAX: 02-888-7295   COPYRIGHTS© 2006 APML ALL RIGHTS RESERVED